Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

doi:10.1016/j.jaci.2016.03.059

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Article

Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

The Journal of allergy and clinical immunology - 1 Feb 2017

Chen Hannah H, Händel Norman, Ngeow Joanne, Muller James, Hühn Michael, Yang Huei-Ting, Heindl Mario, Berbers Roos-Marijn, Hegazy Ahmed N, Kionke Janina, Yehia Lamis, Sack Ulrich, Bläser Frank, Rensing-Ehl Anne, Reifenberger Julia, Keith Julia, Travis Simon, Merkenschlager Andreas, Kiess Wieland, Wittekind Christian, Walker Lisa, Ehl Stephan, Aretz Stefan, Dustin Michael L, Eng Charis, Powrie Fiona, Uhlig Holm H

Abstract excerpt

BACKGROUND: Patients with heterozygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experience autoimmunity and lymphoid hyperplasia. OBJECTIVES: Because regulation of the phosphoinositide 3-kinase (PI3K) pathway is critical for maintaining regulatory T (Treg) cell functions, we investigate Treg cells in patients with heterozygous germline PTEN mutations (PTEN hamartoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27477328
DOI: 10.1016/j.jaci.2016.03.059
PMCID: PMC5292998

Genes

PTEN
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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