Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.

Cellular & molecular immunology - 1 Feb 2021

Permanyer Marc, Bošnjak Berislav, Glage Silke, Friedrichsen Michaela, Floess Stefan, Huehn Jochen, Patzer Gwendolyn E, Odak Ivan, Eckert Nadine, Zargari Razieh, Ospina-Quintero Laura, Georgiev Hristo, Förster Reinhold

Abstract excerpt

Signaling via interleukin-2 receptor (IL-2R) is a requisite for regulatory T (Treg) cell identity and function. However, it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis, lineage stability and function in both resting and inflammatory conditions. Here, we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Immunosuppression Therapy

Share to Interleukin-2

Share to Interleukin-2 Receptor alpha Subunit

Share to Mice, Inbred C57BL

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 33408345
DOI: 10.1038/s41423-020-00599-z
PMCID: PMC8027001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.PMID 33408345Read ↗

An essential role for the IL-2 receptor in Treg cell function.Semantic proximity Read ↗

Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.Semantic proximity Read ↗

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.Semantic proximity Read ↗

CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential.Semantic proximity Read ↗

A function for interleukin 2 in Foxp3-expressing regulatory T cells.Semantic proximity Read ↗

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunitySemantic proximity Read ↗

Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.Semantic proximity Read ↗

Regulatory T Cell Function in Established Systemic Autoimmune Inflammation: Reversal and Containment of a Fatal DiseaseSemantic proximity Read ↗

RORγt serine 182 tightly regulates T cell heterogeneity to maintain mucosal homeostasis and restrict tissue inflammationSemantic proximity Read ↗

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Semantic proximity Read ↗

Inborn errors of regulatory T-cell differentiation and function.Semantic proximity Read ↗

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.