Article
A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA.
Molecular and cellular biology - 1 Jun 2014
Zhang Bing, Gunawardane Lalith, Niazi Farshad, Jahanbani Fereshteh, Chen Xin, Valadkhan Saba
Abstract excerpt
The ubiquitous presence of long noncoding RNAs (lncRNAs) in eukaryotes points to the importance of understanding how their sequences impact function. As many lncRNAs regulate nuclear events and thus must localize to nuclei, we analyzed the sequence requirements for nuclear localization in an intergenic lncRNA named BORG (BMP2-OP1-responsive gene), which is both spliced and polyadenylated but is strictly localized...
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