Article

Structure of human cytoplasmic Pol II complex explains global transcription repression by Gdown1

2025-12-11

Abstract excerpt

RNA polymerase II (Pol II) is a 12-subunit enzyme crucial for gene transcription in the nucleus. However, its assembly in the cytoplasm, nuclear import, and nuclear function of assembly factors remain poorly understood. Here, we isolated Pol II from the cytoplasmic fraction of human cells (cfPol II) and determined its cryo-EM structure. The structure reveals that Pol II is fully assembled in the cytoplasm before n...

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Literature Corpus work: 64c0c767-ca2a-523a-8fad-cb02b9e2b398
DOI: 10.64898/2025.12.10.693371

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