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Article

Nuclear import of chromatin remodeler Isw1 is mediated by atypical bipartite cNLS and classical import pathway.

Traffic (Copenhagen, Denmark) - 1 Feb 2013

Vasicova Pavla, Stradalova Vendula, Halada Petr, Hasek Jiri, Malcova Ivana

Abstract excerpt

The protein Isw1 of Saccharomyces cerevisiae is an imitation-switch chromatin-remodeling factor. We studied the mechanisms of its nuclear import and found that the nuclear localization signal (NLS) mediating the transport of Isw1 into the nucleus is located at the end of the C-terminus of the protein (aa1079-1105). We show that it is an atypical bipartite signal with an unconventional linker of 19 aa (KRIR X(19)...

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PMID: 23121014
DOI: 10.1111/tra.12025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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