Article
Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.
Molecular cell - 20 Mar 2025
Ge Tiffany, Brickner Donna Garvey, Zehr Kara, VanBelzen D Jake, Zhang Wenzhu, Caffalette Christopher, Moeller Gavin C, Ungerleider Sara, Marcou Nikita, Jacob Alexis, Nguyen Vu Q, Chait Brian, Rout Michael P, Brickner Jason H
Abstract excerpt
Nuclear pore proteins (nucleoporins [Nups]) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters. To define the molecular basis of this mechanism, we exploited a separation-of-function mutation in the Gcn4 transcription factor that blocks its interaction with the nuclear pore complex (NPC)....
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