Article

Structure of cytoplasmic RNA polymerase II

2025-12-10

Abstract excerpt

RNA polymerase II (Pol II) must be assembled in the cytoplasm before it enters the nucleus, where it transcribes protein-coding genes. Although transcription by Pol II is intensively studied, how this central multi-subunit enzyme is made and the role of dedicated factors remains unclear. Here, we report the integrative structural analysis of a native human Pol II from the cytoplasm captured near the end of biogene...

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Literature Corpus work: 4249fea2-d7d8-59e4-9519-cb0783c00a19
DOI: 10.64898/2025.12.10.692585

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