Article

Importins recognize the winged-helix fold of ETS transcription factors to mediate nuclear import

2026-01-06

Abstract excerpt

Protein trafficking between the cytoplasm and the nucleus is a fundamental process in eukaryotic cell biology. While linear nuclear localization signals (NLSs) are well-characterized, many nuclear proteins lack a predictable NLS. Here, we identify the ETS domain, a DNA-binding winged-helix fold, from ETS family transcription factors as a structure-encoded NLS. We show that ETS domains mediate nuclear import throug...

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Literature Corpus work: d2c10d18-3237-52b0-a470-a729596ac844
DOI: 10.64898/2026.01.06.697953

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