Article

Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes

2026-01-14

Abstract excerpt

<h4>ABSTRACT</h4> The nucleosome acidic patch is a hub of coordinated engagement by proteins that regulate genomic function. Here we report that S. cerevisiae Dot5 contains an arginine-rich HMGN-like motif that mediates nucleosome acidic patch binding and is required for the cell growth, DNA repair and heterochromatin defects exhibited when the protein is overexpressed. The heterologous expression of camelid sin...

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Literature Corpus work: bbefb2c5-eeda-5fa6-b35e-daa0c0765727
DOI: 10.64898/2026.01.14.699602

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