Article

Persistence of backtracking by human RNA polymerase II

2023-12-14

Abstract excerpt

<h4>Summary</h4> RNA polymerase II (pol II) can backtrack during transcription elongation, exposing the 3’ end of nascent RNA. Nascent RNA sequencing can approximate the location of backtracking events that are quickly resolved; however, the extent and genome wide distribution of more persistent backtracking is unknown. Consequently, we developed a novel method to directly sequence the extruded, “backtracked” 3’...

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Literature Corpus work: ff3b3a53-41e6-5e01-8bf6-4b9641ee5d10
DOI: 10.1101/2023.12.13.571520

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