Article

A sequence-encoded promoter proximal super pause stabilizes an offline RNA polymerase II state

2026-02-18

Abstract excerpt

Promoter proximal pausing by RNA polymerase II is critical for regulating gene expression in multicellular eukaryotes. How nucleic acid sequence and protein factors contribute to pausing remains incompletely understood. We developed Gene-specific Analysis of Transcriptional Output (GATO)-seq, which for the first time enables massively parallel, temporally resolved, reconstituted transcription in an assay that uses...

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Literature Corpus work: dcc98ca8-9cc3-5f23-a5c7-022854866d4a
DOI: 10.64898/2026.02.18.706689

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