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Article

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons.

eLife - 29 Apr 2014

Jonkers Iris, Kwak Hojoong, Lis John T

Abstract excerpt

Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation. To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either initiation or promoter-proximal pause escape with Triptolide or Flavopiridol, and tracked Pol II kinetically using GRO-seq. Both inhibitors block transcription of more than 95% of genes, showing that pause escape, like initiation, is...

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Identifiers

PMID: 24843027
DOI: 10.7554/eLife.02407
PMCID: PMC4001325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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