Article

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation

2023-03-06

Abstract excerpt

<h4>Summary</h4> The controlled release of promoter-proximal paused RNA polymerase II (Pol II) into productive elongation is a major step in gene regulation. However, functional analysis of Pol II pausing is difficult because factors that regulate pause release are almost all essential. In this study, we identified heterozygous loss-of-function mutations in SUPT5H , which encodes SPT5, in individuals with β-thalas...

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Literature Corpus work: 748cc4c6-6870-5c15-b0ff-4f952ed6c661
DOI: 10.1101/2023.03.03.23286760

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