Article

Transcription drives DNA replication initiation and termination in human cells

2018-05-16

Abstract excerpt

<h4>ABSTRACT</h4> The locations of active DNA replication origins in the human genome, and the determinants of origin activation, remain controversial. Additionally, neither the predominant sites of replication termination nor the impact of transcription on replication-fork mobility have been defined. We demonstrate that replication initiation occurs preferentially in the immediate vicinity of the transcription s...

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Identifiers and source

Literature Corpus work: e5c0fa37-86ef-575a-a227-49dfd2c08958
DOI: 10.1101/324079

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