Article

Gene body H2B monoubiquitylation regulates gene-selective RNA Polymerase II pause release and is not rate limiting for transcription elongation

2015-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Histone H2B monoubiquitylation (H2Bub1) is localized preferentially to transcribed regions of genes and spreads concomitantly with the progression of RNA polymerase II (Pol II). In mammalian cells, H2Bub1 levels are highly correlated with transcription elongation rates, consistent with the general belief that H2Bub1 facilitates the elongation process. Yet, a causative role of H2Bub1 in regulatin...

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Literature Corpus work: 78ba34d4-d47e-5e1b-9cbe-eb57384440f9
DOI: 10.1101/035386

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