Article

Global landscape of replicative DNA polymerase usage in the human genome

2021-11-14

Abstract excerpt

The division of labour among DNA polymerase underlies the accuracy and efficiency of replication. However, the roles of replicative polymerases have not been directly established in human cells. We developed polymerase usage sequence (Pu-seq) in HCT116 cells and mapped Polε and Polα usage genome wide. The polymerase usage profiles show Polε synthesises the leading strand and Polα contributes mainly to lagging stra...

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Literature Corpus work: 35a866f2-f8be-50c8-886c-ca9e6de11948
DOI: 10.1101/2021.11.14.468503

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