Article

RNA degradation by DIS3 is a necessary step in the resolution of backtracked transcription complexes

2026-02-02

Abstract excerpt

<h4>Summary</h4> The RNA exosome is known to participate in transcription, but the contribution of its ribonuclease activities to this process remains unclear. Here we investigated the role of DIS3, one of the exosome ribonucleases, in transcription by RNA polymerase II (RNAPII). Rapid depletion of DIS3 reduced RNA synthesis and induced RNAPII elongation defects that were exacerbated by UV irradiation, a treatmen...

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Literature Corpus work: 89be4ca1-d5f3-5f99-aad9-0013d0fd1aae
DOI: 10.64898/2026.02.02.703186

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