Article

Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiation

2023-12-05

Abstract excerpt

DNA is folded into higher-order structures that shape and are shaped by genome function. The role for long-range loops in the establishment of new gene expression patterns during cell fate transitions remains poorly understood. Here, we investigate the link between cell-specific loops and RNA polymerase II (RNAPolII) during neural lineage commitment. We find thousands of loops decommissioned or gained de novo upo...

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Literature Corpus work: db469049-0bd2-54c6-8061-6a8333039af1
DOI: 10.1101/2023.12.04.569731

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