Back to search

Article

An Alternative DNA Endonuclease Activity is Associated with the LINE-1 ORF2-encoded Protein

2026-01-20

Abstract excerpt

Long INterspersed Element-1 (L1) retrotransposons use activities contained within the L1 open reading frame 2-encoded protein (ORF2p) to mobilize throughout the genome via target-site primed reverse transcription (TPRT). The ORF2p endonuclease domain (EN) cleaves genomic DNA to liberate a 3’-hydroxyl (3’-OH) group that is used by the ORF2p reverse transcriptase domain (RT) to synthesize a cDNA copy of its bound L1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fef41ff0-d4a2-517c-9551-1742788a742b
DOI
10.64898/2026.01.20.700639
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An Alternative DNA Endonuclease Activity is Associated with the LINE-1 ORF2-encoded ProteinDOI 10.64898/2026.01.20.700639
Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase.Semantic proximity
LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?Semantic proximity
Characterization of LINE-1 ribonucleoprotein particles.Semantic proximity
A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage?Semantic proximity
Comprehensive scanning mutagenesis of human retrotransposon LINE-1 identifies motifs essential for functionSemantic proximity
Dissection of purified LINE-1 reveals distinct nuclear and cytoplasmic intermediatesSemantic proximity
Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function.Semantic proximity
Robust expression of LINE-1 retrotransposon encoded proteins in oral squamous cell carcinomaSemantic proximity
Truncated ORF1 proteins can suppress LINE-1 retrotransposition in trans.Semantic proximity
LINE-1 ribonucleoprotein complexes bind DNA to enable nuclear entry during mitosisSemantic proximity
Circular retrotransposition products generated by a LINE retrotransposon.Semantic proximity
LINE-1 ORF2p Expression is Nearly Imperceptible in Human CancersSemantic proximity
Select a neighboring publication to make it the new centre.