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Article

LINE-1 ORF2p Expression is Nearly Imperceptible in Human Cancers

2019-08-22

Abstract excerpt

<h4> A bstract </h4> <h4>Background</h4> Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and ORF2p. Many types of human cancers are characterized by L1 promoter hypomethylation, L1 transcription, L1 ORF1p protein expression, and somatic...

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Literature Corpus work
c15a2933-acb5-5e7a-b5d5-e2867d2be7a1
DOI
10.1101/744425
Open publication

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LINE-1 ORF2p Expression is Nearly Imperceptible in Human CancersDOI 10.1101/744425
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