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Article

LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 2005

Han Jeffrey S, Boeke Jef D

Abstract excerpt

LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA-binding protein, and ORF2, an endonuclease/reverse transcriptase. Both proteins are required for L1 mobilization. Apart from the obvious...

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PMID: 16015595
DOI: 10.1002/bies.20257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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