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Article

A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage?

Mechanisms of ageing and development - 1 May 2010

St Laurent Georges, Hammell Neil, McCaffrey Timothy A

Abstract excerpt

Advancing age remains the largest risk factor for devastating diseases, such as heart disease, stroke, and cancer. The mechanisms by which advancing age predisposes to disease are now beginning to unfold, due in part, to genetic and environmental manipulations of longevity in lower organisms. Converging lines of evidence suggest that DNA damage may be a final common pathway linking several proposed mechanisms of...

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Identifiers

PMID: 20346965
DOI: 10.1016/j.mad.2010.03.008
PMCID: PMC2875337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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