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Article

Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011

Kopera Huira C, Moldovan John B, Morrish Tammy A, Garcia-Perez Jose Luis, Moran John V

Abstract excerpt

Long interspersed element-1 (LINE-1 or L1) retrotransposons encode two proteins (ORF1p and ORF2p) that contain activities required for conventional retrotransposition by a mechanism termed target-site primed reverse transcription. Previous experiments in XRCC4 or DNA protein kinase catalytic subunit-deficient CHO cell lines, which are defective for the nonhomologous end-joining DNA repair pathway, revealed an...

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Identifiers

PMID: 21940498
DOI: 10.1073/pnas.1100275108
PMCID: PMC3251045

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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