Article

LINE-1 ribonucleoprotein complexes bind DNA to enable nuclear entry during mitosis

2024-10-02

Abstract excerpt

<h4>Summary</h4> Long Interspersed Nuclear Element-1 (LINE-1) is an autonomous retrotransposon that makes up a significant portion of the human genome, contributing to genetic diversity and genome evolution. LINE-1 encodes two proteins, ORF1p and ORF2p, both essential for successful retrotransposition. ORF2p has endonuclease and reverse transcription activity, while ORF1p binds RNA. Many copies of ORF1p assemble...

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Literature Corpus work: 788b5681-d55a-5366-85b5-6f99366f1aa7
DOI: 10.1101/2024.10.01.616040

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