Article
Circular retrotransposition products generated by a LINE retrotransposon.
Nucleic acids research - 1 Nov 2012
Han Jeffrey S, Shao Shirley
Abstract excerpt
Non-long terminal repeat (non-LTR) retrotransposons are highly abundant elements that are present in chromosomes throughout the eukaryotic domain of life. The long interspersed nuclear element (LINE-1) (L1) clade of non-LTR retrotransposons has been particularly successful in mammals, accounting for 30-40% of human genome sequence. The current model of LINE retrotransposition, target-primed reverse transcription,...
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