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Article

Comprehensive scanning mutagenesis of human retrotransposon LINE-1 identifies motifs essential for function

2019-08-01

Abstract excerpt

Long Interspersed Nuclear Element-1 (LINE-1, L1) is the only autonomous active transposable element in the human genome. The L1-encoded proteins ORF1p and ORF2p enable the element to jump from one locus to another via a “copy and paste” mechanism. ORF1p is an RNA-binding protein and ORF2p has endonuclease and reverse transcriptase activities. The huge number of truncated L1 remnants in the human genome suggests th...

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Identifiers and source

Literature Corpus work
2eb99dbe-0a7c-5f54-879a-56ac04f8ccca
DOI
10.1101/721357
Open publication

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Comprehensive scanning mutagenesis of human retrotransposon LINE-1 identifies motifs essential for functionDOI 10.1101/721357
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