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Article

Truncated ORF1 proteins can suppress LINE-1 retrotransposition in trans.

Nucleic acids research - 19 May 2017

Sokolowski Mark, Chynces May, deHaro Dawn, Christian Claiborne M, Belancio Victoria P

Abstract excerpt

Long interspersed element 1 (L1) is an autonomous non-LTR retroelement that is active in mammalian genomes. Although retrotranspositionally incompetent and functional L1 loci are present in the same genomes, it remains unknown whether non-functional L1s have any trans effect on mobilization of active elements. Using bioinformatic analysis, we identified over a thousand of human L1 loci containing at least one...

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PMID: 28431148
DOI: 10.1093/nar/gkx211
PMCID: PMC5605252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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