Article
Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function.
Genetics - 1 Dec 2019
Adney Emily M, Ochmann Matthias T, Sil Srinjoy, Truong David M, Mita Paolo, Wang Xuya, Kahler David J, Fenyö David, Holt Liam J, Boeke Jef D
Abstract excerpt
Long Interspersed Nuclear Element-1 (LINE-1, L1) is the only autonomous active transposable element in the human genome. The L1-encoded proteins ORF1p and ORF2p enable the element to jump from one locus to another via a "copy-and-paste" mechanism. ORF1p is an RNA-binding protein, and ORF2p has endonuclease and reverse transcriptase activities. The huge number of truncated L1 remnants in the human genome suggests...
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