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Article

Characterization of LINE-1 ribonucleoprotein particles.

PLoS genetics - 7 Oct 2010

Doucet Aurélien J, Hulme Amy E, Sahinovic Elodie, Kulpa Deanna A, Moldovan John B, Kopera Huira C, Athanikar Jyoti N, Hasnaoui Manel, Bucheton Alain, Moran John V, Gilbert Nicolas

Abstract excerpt

The average human genome contains a small cohort of active L1 retrotransposons that encode two proteins (ORF1p and ORF2p) required for their mobility (i.e., retrotransposition). Prior studies demonstrated that human ORF1p, L1 RNA, and an ORF2p-encoded reverse transcriptase activity are present in ribonucleoprotein (RNP) complexes. However, the inability to physically detect ORF2p from engineered human L1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Identifiers

PMID: 20949108
DOI: 10.1371/journal.pgen.1001150
PMCID: PMC2951350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of LINE-1 ribonucleoprotein particles.PMID 20949108Read ↗

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