Article

Modelling Crebbp loss in BCL2 driven non-Hodgkin's lymphoma

2016-01-01

Abstract excerpt

Non-Hodgkin’s lymphomas (NHL) are a spectrum of hematopoietic cancer accounting for 4% of new cancer diagnoses each year. Approximately 95% of all NHL are of B-cell origin; diffuse large B-cell lymphomas (DLBCL) and follicular lymphoma (FL) accounting for 30-40% and 20% of B-NHL respectively. Recent human mutation profiling and resequencing studies have shown that CREBBP and BCL2 are frequently mutated, early even...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fec8825b-3300-574b-a6c8-c9799ede27b3
DOI: 10.25560/58194

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modelling Crebbp loss in BCL2 driven non-Hodgkin's lymphomaDOI 10.25560/58194Read

Mutational synergy with <i>CREBBP</i> loss in lymphomagenesis identified through forward insertional mutagenesis in a new DLBCL mouse modelSemantic proximity Read

Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.Semantic proximity Read

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell LymphomaSemantic proximity Read

Analysis of Bcl6 in a genetically tractable human B cell lineSemantic proximity Read

Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors.Semantic proximity Read

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.Semantic proximity Read

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomasSemantic proximity Read

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.Semantic proximity Read

Essentiality of <i>CREBBP</i> in <i>EP300</i> truncated B-cell lymphoma revealed by genome-wide CRISPR-Cas9 screenSemantic proximity Read

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.Semantic proximity Read

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphomaSemantic proximity Read

Stress Induced Signaling Pathways in Burkitt’s Lymphoma Play Novel Mechanisms in Fate Determination and Pathogenesis of Germinal Center-Derived B-LymphomasSemantic proximity Read