Article
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
Cancer discovery - 1 Jan 2017
Jiang Yanwen, Ortega-Molina Ana, Geng Huimin, Ying Hsia-Yuan, Hatzi Katerina, Parsa Sara, McNally Dylan, Wang Ling, Doane Ashley S, Agirre Xabier, Teater Matt, Meydan Cem, Li Zhuoning, Poloway David, Wang Shenqiu, Ennishi Daisuke, Scott David W, Stengel Kristy R, Kranz Janice E, Holson Edward, Sharma Sneh, Young James W, Chu Chi-Shuen, Roeder Robert G, Shaknovich Rita, Hiebert Scott W, Gascoyne Randy D, Tam Wayne, Elemento Olivier, Wendel Hans-Guido, Melnick Ari M
Abstract excerpt
Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center (GC)-derived lymphomas in mice. In both human and murine lymphomas, CREBBP loss-of-function resulted in focal depletion of enhancer H3K27 acetylation and aberrant transcriptional silencing of genes that regulate B-cell signaling and immune responses, including class II...
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