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Article

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.

Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2017

Hashwah Hind, Schmid Corina A, Kasser Sabrina, Bertram Katrin, Stelling Anna, Manz Markus G, Müller Anne

Abstract excerpt

The genes encoding the histone acetyl-transferases (HATs) CREB binding protein (CREBBP) and EP300 are recurrently mutated in the activated B cell-like and germinal center (GC) B cell-like subtypes of diffuse large B cell lymphoma (DLBCL). Here, we introduced a patient mutation into a human DLBCL cell line using CRISPR and deleted Crebbp and Ep300 in the GC B cell compartment of mice. CREBBP-mutant DLBCL clones...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to E1A-Associated p300 Protein

Share to Genes, MHC Class II

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Share to Lymphoma, Large B-Cell, Diffuse

Source

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Identifiers

PMID: 28831000
DOI: 10.1073/pnas.1619555114
PMCID: PMC5594639

Genes

CREBBP
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.PMID 28831000Read ↗

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