Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.

doi:10.1182/blood-2016-08-733469

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Article

Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.

Blood - 11 May 2017

García-Ramírez Idoia, Tadros Saber, González-Herrero Inés, Martín-Lorenzo Alberto, Rodríguez-Hernández Guillermo, Moore Dalia, Ruiz-Roca Lucía, Blanco Oscar, Alonso-López Diego, Rivas Javier De Las, Hartert Keenan, Duval Romain, Klinkebiel David, Bast Martin, Vose Julie, Lunning Matthew, Fu Kai, Greiner Timothy, Rodrigues-Lima Fernando, Jiménez Rafael, Criado Francisco Javier García, Cenador María Begoña García, Brindle Paul, Vicente-Dueñas Carolina, Alizadeh Ash, Sánchez-García Isidro, Green Michael R

Abstract excerpt

CREBBP is targeted by inactivating mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Here, we provide evidence from transgenic mouse models that Crebbp deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma. Through transcriptional and epigenetic profiling of these B cells, we found that Crebbp inactivation was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CREB-Binding Protein

Share to Epigenesis, Genetic

Share to Gene Deletion

Share to Gene Expression Regulation, Neoplastic

Share to Lymphoma, Follicular

Share to Lymphoma, Large B-Cell, Diffuse

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Identifiers

PMID: 28288979
DOI: 10.1182/blood-2016-08-733469
PMCID: PMC5428458

Genes

CREBBP

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