Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma

9 Jan 2017

Abstract excerpt

Abstract Inactivating mutations of the CREBBP acetyltransferase are highly frequent in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), the two most common germinal center (GC)–derived cancers. However, the role of CREBBP inactivation in lymphomagenesis remains unclear. Here, we show that CREBBP regulates enhancer/super-enhancer networks with central roles in GC/post-GC cell fate decisions,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Lymphoma Diagnosis and Treatment
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28069569
DOI: 10.1158/2159-8290.cd-16-1417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell LymphomaPMID 28069569Read ↗

Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement.Semantic proximity Read ↗

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.Semantic proximity Read ↗

Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.Semantic proximity Read ↗

Inactivating mutations of acetyltransferase genes in B-cell lymphoma.Semantic proximity Read ↗

Mutational synergy with <i>CREBBP</i> loss in lymphomagenesis identified through forward insertional mutagenesis in a new DLBCL mouse modelSemantic proximity Read ↗

KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.Semantic proximity Read ↗

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphomaSemantic proximity Read ↗

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancySemantic proximity Read ↗

Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.Semantic proximity Read ↗

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphomaSemantic proximity Read ↗

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.Semantic proximity Read ↗

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.