Article

Stress Induced Signaling Pathways in Burkitt’s Lymphoma Play Novel Mechanisms in Fate Determination and Pathogenesis of Germinal Center-Derived B-Lymphomas

2024-12-20

Abstract excerpt

B cell receptor signaling, NF-κB signaling, BCL6 and p53 regulation are essential for germinal center (GC) B cell fate. Dysregulation of these pathways drives the pathogenesis and treatment resistance of GC-derived B-lymphomas (GCDBL). To explore how these pathways affect GCDBL fate and pathogenesis, we treated Raji cells (a GCDBL and Burkitt’s lymphoma) with mild hydroxyurea (HU) to simulate genotoxic stress enco...

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Literature Corpus work: 316f63b2-3345-5bee-ae00-394c7cffed33
DOI: 10.1101/2024.12.19.628635

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