Mutational synergy with <i>CREBBP</i> loss in lymphomagenesis identified through forward insertional mutagenesis in a new DLBCL mouse model

Abstract excerpt

Loss-of-function mutations in the gene encoding the acetyltransferase CREBBP have been reported in numerous cancers but are particularly frequent in lymphoid malignancies. However, the functional significance of CREBBP loss in transformation and disease progression, most likely through cooperation with secondary genetic hits, has not yet been fully unravelled. Similarly, the contribution of the initial cell popula...

Topics

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• CREB-Binding Protein
• CRISPR-Cas Systems
• E1A-Associated p300 Protein
• Genes, MHC Class II
• Germinal Center
• Heterografts
• Histone Code
• Lymphoma, Large B-Cell, Diffuse

Identifiers and source

Literature Corpus work

b3ae87ba-446a-52ca-8b7b-e29d91ba19cb

DOI

10.1101/2024.03.25.586554