Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.

doi:10.1038/ncb3597

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Article

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.

Nature cell biology - 1 Sept 2017

Horton Sarah J, Giotopoulos George, Yun Haiyang, Vohra Shabana, Sheppard Olivia, Bashford-Rogers Rachael, Rashid Mamunur, Clipson Alexandra, Chan Wai-In, Sasca Daniel, Yiangou Loukia, Osaki Hikari, Basheer Faisal, Gallipoli Paolo, Burrows Natalie, Erdem Ayşegül, Sybirna Anastasiya, Foerster Sarah, Zhao Wanfeng, Sustic Tonci, Petrunkina Harrison Anna, Laurenti Elisa, Okosun Jessica, Hodson Daniel, Wright Penny, Smith Ken G, Maxwell Patrick, Fitzgibbon Jude, Du Ming Q, Adams David J, Huntly Brian J P

Abstract excerpt

Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour suppressor functions of CREBBP remain unclear. We demonstrate that loss of Crebbp in murine haematopoietic stem and progenitor cells (HSPCs) leads to increased development of B-cell lymphomas. This is preceded by accumulation of hyperproliferative lymphoid...

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Identifiers

PMID: 28825697
DOI: 10.1038/ncb3597
PMCID: PMC5633079

Genes

CREBBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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