Article

Essentiality of <i>CREBBP</i> in <i>EP300</i> truncated B-cell lymphoma revealed by genome-wide CRISPR-Cas9 screen

2019-08-28

Abstract excerpt

Histone acetyltransferases (HATs), including CREBBP and EP300 , are frequently mutated in B-cell malignancies and usually play a tumor-suppressive role. In this study, we performed whole genome and transcriptome sequencing and a genome-wide CRISPR-Cas9 knockout screen to study a germinal center B-cell like diffuse large B-cell lymphoma (DLBCL) cell line (RC-K8). Using a summarizing method that is optimized to ad...

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Literature Corpus work: 5fb87de1-4d1d-5564-9cb3-4252525534b3
DOI: 10.1101/746594

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