Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors.

Cancer discovery - 2 Jun 2023

Schroers-Martin Joseph G, Soo Joanne, Brisou Gabriel, Scherer Florian, Kurtz David M, Sworder Brian J, Khodadoust Michael S, Jin Michael C, Bru Agnès, Liu Chih Long, Stehr Henning, Vineis Paolo, Natkunam Yasodha, Teras Lauren R, Song Joo Y, Nadel Bertrand, Diehn Maximilian, Roulland Sandrine, Alizadeh Ash A

Abstract excerpt

Follicular lymphomas (FL) are characterized by BCL2 translocations, often detectable in blood years before FL diagnosis, but also observed in aging healthy individuals, suggesting additional lesions are required for lymphomagenesis. We directly characterized early cooperating mutations by ultradeep sequencing of prediagnostic blood and tissue specimens from 48 subjects who ultimately developed FL. Strikingly,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Chronic Lymphocytic Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Lymphoma Diagnosis and Treatment

Share to Lymphoma, Follicular

Share to Mutation

Share to Proto-Oncogene Proteins c-bcl-2

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 36939219
DOI: 10.1158/2159-8290.CD-23-0111
PMCID: PMC10239329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors.PMID 36939219Read ↗

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.Semantic proximity Read ↗

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma.Semantic proximity Read ↗

Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma.Semantic proximity Read ↗

Genomic landscape of follicular lymphoma across a wide spectrum of clinical behaviors.Semantic proximity Read ↗

Follicular lymphoma, a B cell malignancy addicted to epigenetic mutations.Semantic proximity Read ↗

Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma.Semantic proximity Read ↗

From genetics to the clinic: a translational perspective on follicular lymphoma.Semantic proximity Read ↗

Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns.Semantic proximity Read ↗

Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes.Semantic proximity Read ↗

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.Semantic proximity Read ↗

The molecular ontogeny of follicular lymphoma: gene mutations succeeding the BCL2 translocation define common precursor cells.Semantic proximity Read ↗

Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.