Article

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma

2019-01-27

Abstract excerpt

CREBBP mutations are highly recurrent in B-cell lymphomas and either inactivate its histone acetyltransferase (HAT) domain or truncate the protein. Herein, we show that these two classes of mutations yield different degrees of disruption of the epigenome, with HAT mutations being more severe and associated with inferior clinical outcome. Genes perturbed by CREBBP mutation are direct targets of the BCL6/HDAC3 onco...

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Literature Corpus work: 38a9a9c1-1753-5875-93de-d52708db9085
DOI: 10.1101/531954

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