Article

Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells

2022-04-08

Abstract excerpt

In human embryos, naive pluripotent cells of the inner cell mass generate epiblast, primitive endoderm and Trophectoderm (TE) lineage, whence trophoblast cells derive. In vitro , naive pluripotent stem cells (PSCs) retain this potential and can generate trophoblast stem cells (TSCs), while conventional PSCs form amnion-like cells and lack the competence to generate TSCs. Transient histone deacetylase and MEK inhi...

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Literature Corpus work: fe1ac4bf-0b02-5457-b4f7-b65b8d6799f5
DOI: 10.1101/2022.04.07.487453

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