Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive state

8 Feb 2024

Abstract excerpt

Primary human trophoblast stem cells (TSCs) and TSCs derived from human pluripotent stem cells (hPSCs) can potentially model placental processes in vitro. Yet, the pluripotent states and factors involved in the differentiation of hPSCs to TSCs remain poorly understood. In this study, we demonstrate that the primed pluripotent state can generate TSCs by activating pathways such as Epidermal Growth Factor (EGF) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Pluripotent Stem Cells Research
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38332235
DOI: 10.1038/s41598-024-53381-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive statePMID 38332235Read ↗

A single cell trajectory of human archetypal pluripotent stem cell differentiation to trophoblast stem cells reveals induction of endogenous BMP5/7 and GATA3 without transitioning through a naive stateSemantic proximity Read ↗

Derivation of functional trophoblast stem cells from primed human pluripotent stem cellsSemantic proximity Read ↗

Induction of human trophoblast stem-like cells from primed pluripotent stem cellsSemantic proximity Read ↗

Induction of human trophoblast stem-like cells from primed pluripotent stem cellsSemantic proximity Read ↗

Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem CellsSemantic proximity Read ↗

Efficient derivation of human trophoblast stem cells from primed pluripotent stem cellsSemantic proximity Read ↗

Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming InnovationsSemantic proximity Read ↗

The product of BMP-directed differentiation protocols for human primed pluripotent stem cells is placental trophoblast and not amnionSemantic proximity Read ↗

Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure.Semantic proximity Read ↗

Human Naïve Epiblast Cells Possess Unrestricted Lineage PotentialSemantic proximity Read ↗

Cell-autonomous differentiation of human primed embryonic stem cells into trophoblastic syncytia through the nascent amnion-like cell stateSemantic proximity Read ↗

Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.