Article

Transient let-7/miR-98 reprograms primed pluripotency to induce naive human PSCs

2025-10-15

Abstract excerpt

<h4>Summary</h4> Naive human pluripotent stem cells (hPSCs) are valuable for modeling early development and enabling regenerative applications, yet resetting from the primed state remains inefficient and mechanistically unclear. We identify an unexpected role for miR-98-5p, a let-7 family microRNA (miRNA) typically linked to differentiation, in promoting naive induction. Using a synthetic mRNA screen containing d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 065e8ddb-5da9-5e0c-b7f6-d598b47c28c2
DOI: 10.1101/2025.10.14.682465

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transient let-7/miR-98 reprograms primed pluripotency to induce naive human PSCsDOI 10.1101/2025.10.14.682465Read

Epigenetic resetting of human pluripotencySemantic proximity Read

Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution.Semantic proximity Read

AMPK-p38 axis converts human pluripotent stem cells to naïve stateSemantic proximity Read

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cellsSemantic proximity Read

Single Cell Sequencing Reveals Early PGC-like Intermediates During Mouse Primed to Naïve TransitionSemantic proximity Read

Deciphering the mRNA-lncRNA-miRNA interaction landscape in human pluripotencySemantic proximity Read

Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene networkSemantic proximity Read

A novel microRNA-based strategy to expand the differentiation potency of stem cellsSemantic proximity Read

Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem CellsSemantic proximity Read

Resistance to Naïve and Formative Pluripotency Conversion in RSeT Human Embryonic Stem CellsSemantic proximity Read

Efficient RNA-mediated reprogramming of human somatic cells to naïve pluripotency facilitated by tankyrase inhibitionSemantic proximity Read

Tracing the Transitions from Pluripotency to Germ Cell Fate with CRISPR ScreeningSemantic proximity Read