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Derivation of functional trophoblast stem cells from primed human pluripotent stem cells

19 May 2022

Abstract excerpt

Trophoblast stem cells (TSCs) have recently been derived from human embryos and early-first-trimester placenta; however, aside from ethical challenges, the unknown disease potential of these cells limits their scientific utility. We have previously established a bone morphogetic protein 4 (BMP4)-based two-step protocol for differentiation of primed human pluripotent stem cells (hPSCs) into functional...

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PMID: 35594858
DOI: 10.1016/j.stemcr.2022.04.013

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