Article

Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network

2023-04-13

Abstract excerpt

<h4>Summary</h4> Human pluripotent stem cells (hPSCs) can self-organize into a blastocyst-like structure (blastoid) by virtue of their full developmental potential. The pluripotent mouse embryonic stem cells (mESC) are considered to lack this potential and hence can form blastoids only when combined with trophoblast stem cells. We performed a small molecule and cytokine screen to demonstrate that mESC have full p...

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Literature Corpus work: bce37050-a941-5228-b3fd-3b446343ceff
DOI: 10.1101/2023.04.12.536583

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