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Article

Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential

2020-02-04

Abstract excerpt

<h4>SUMMARY</h4> Classical mouse embryology has established a paradigm of early development driven by sequential lineage bifurcations. Accordingly, mouse embryonic stem cells derived from early epiblast have lost the potency to produce extraembryonic trophectoderm. We show in contrast that human naïve epiblast cells readily make trophectoderm. Inhibition of ERK signalling, instrumental in naïve stem cell propagat...

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Identifiers and source

Literature Corpus work
aa5d599c-7211-5b37-913f-1395afbc06e6
DOI
10.1101/2020.02.04.933812
Open publication

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Human Naïve Epiblast Cells Possess Unrestricted Lineage PotentialDOI 10.1101/2020.02.04.933812
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