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Article

Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution.

Stem cell reports - 11 Mar 2025

Fischer Laura A, Meyer Brittany, Reyes Monica, Zemke Joseph E, Harrison Jessica K, Park Kyoung-Mi, Wang Ting, Jüppner Harald, Dietmann Sabine, Theunissen Thorold W

Abstract excerpt

Naive human pluripotent stem cells (hPSCs) model the pre-implantation epiblast. However, parent-specific epigenetic marks (imprints) are eroded in naive hPSCs, which represents an important deviation from the epiblast in vivo. To track the dynamics of imprint erasure during naive resetting in real time, we established a dual-colored fluorescent reporter at both alleles of the imprinted SNRPN locus. During...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39952244
DOI: 10.1016/j.stemcr.2025.102419
PMCID: PMC11960550

Genes

SNRPN
ZFP57

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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