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From the stem of the placental tree: trophoblast stem cells and their progeny

15 Oct 2016

Abstract excerpt

Trophoblast stem cells (TSCs) retain the capacity to self-renew indefinitely and harbour the potential to differentiate into all trophoblast subtypes of the placenta. Recent studies have shown how signalling cascades integrate with transcription factor circuits to govern the fine balance between TSC self-renewal and differentiation. In addition, breakthroughs in reprogramming strategies have enabled the...

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PMID: 27802134
DOI: 10.1242/dev.133462

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