Article

A single cell trajectory of human archetypal pluripotent stem cell differentiation to trophoblast stem cells reveals induction of endogenous BMP5/7 and GATA3 without transitioning through a naive state

2020-08-29

Abstract excerpt

The human placenta is increasingly a focus of research related to early child development and the impact of maternal hyperimmune states. Primary human trophoblast stem cells (hTSC) and human pluripotent stem cells (hPSC) differentiated to hTSC can potentially model placental processes in vitro . Yet, it remains controversial how the differentiation of human pluripotent stem cells to trophectoderm relates to in v...

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Literature Corpus work: e68c0761-f101-56dd-a0e1-6b13e99c5b71
DOI: 10.1101/2020.08.29.273425

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