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Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells

1 Nov 2020

Abstract excerpt

Human trophoblast stem cells (hTSCs) derived from blastocysts and first-trimester cytotrophoblasts offer an unprecedented opportunity to study the placenta. However, access to human embryos and first-trimester placentas is limited, thus preventing the establishment of hTSCs from diverse genetic backgrounds associated with placental disorders. Here, we show that hTSCs can be generated from numerous genetic...

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PMID: 33238118
DOI: 10.1016/j.celrep.2020.108419

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